In New York City, she was accepted by Actors Studio co-founder Elia Kazan after a single audition, becoming the studio’s first Puerto Rican member. In New York, Colón worked in theater and later landed a role on the American daytime soap opera Guiding Light. Between 1954 and 1974, Colón made guest appearances in television shows such as Peter Gunn and Alfred Hitchcock Presents. On television she appeared mostly in westerns such as Gunsmoke, Bonanza, The High Chaparral and Have Gun, Will Travel. Colón also appeared in the 1961 film One-eyed Jacks as “the redhead”. She went on to appear in several other television productions, including The Richest Man In Bogota starring Lee Marvin and the film Gloria starring Sharon Stone (1999).