He has appeared in the films Daddy Day Care, Norbit, and Hip-Hop Headstrong and voiced roles for the movies Barnyard, Happy Feet, The Little Engine That Could, Rise of the Guardians, Cloudy with a Chance of Meatballs 2, and more. Khamani Griffin has also appeared in episodes of the TV series ER, My Name Is Earl, Without a Trace, Carpoolers, Entourage, Navy NCIS: Naval Criminal Investigative Service, Grey’s Anatomy, Are You Smarter Than a 5th Grader?, Brothers & Sisters, Sofia the First, and more. He has been nominated for three Young Artist Awards.