Mezzogiorno won the Coppa Volpi Award, one of the highest honors given to international actresses. She joined the likes of previous award winners such as Shirley MacLaine, Sophia Loren, and Bette Davis. Her more recent appearances include parts in “AD Project”, “Lezioni di Volo”, “Notturno Bus”, “Vincere”, and “Palermo Shooting”. Mezzogiorno is set to appear in 2014’s “I nostril ragazzi” as Clara. She is the mother of two children, sons Zeno and Leone, who were born in 2011.