In 2001 he starred as Francisco Torres in the series Spyder Games. From 2002 to 2009 he starred as FBI agent Danny Taylor in the CBS series Without a Trace. Murciano had a recurring role in the series CSI: Crime Scene Investigation from 2009 to 2012 and the series NCIS from 2011 to 2012. He has starred in the movies Black hawk Down, Case 42, Miss Congeniality 2: Armed and Fabulous, The Lost City, How to Go Out on a Date in Queens, Mancora, Water & Power, and Dawn of the Planet of the Apes. He has been nominated for two ALMA Awards, a Daytime Emmy Award, and a Screen Actors Guild Award. He was listed at #7 on People magazine’s sexiest men alive in 2006.