Clark played for the Miami Dolphins in 2002 and for the Chicago Bears from 2003 to 2010. In 2005 he was selected as a Pro Bowl alternate. He started the non-profit school program 88 Wayz in 2008. He was a broadcaster and hosted the Dez Clark & Alex Brown Show with former teammate Alex Brown. Clark now works as a financial advisor and is President of NFL Alumni for the Chicago Chapter.