In 2005, he starred in the film A History of Violence. In 2006, he had a recurring role on ABC’s Boston Legal and appeared in Peaceful Warrior. He also played a role in What We Do is Secret, Normal Adolescent Behavior, Wind Chill and Smart People. Holmes did television appearances on series such as Law & Order, Numbers, House, Cold Case, CSI and Ghost Whisperer. Most recently, he was in the HBO miniseries The Pacific, CW series Nikita, ABC drama series Revenge and was cast in the ABC pilot Reckless.