Though he was injured during his rookie season, Ogunleye made it onto the field for the Dolphins his second year. He became a Pro Bowler and All-Pro in 2003, the same season he led the AFC in sacks. In 2004, Ogunleye was traded to the Chicago Bears in exchange for a wide receiver and a draft pick. He remained successful with the Bears, appearing in Super Bowl XLI. He signed a one-year deal with the Houston Texans in 2010, the last time Ogunleye would play professional football. He finished his career with 387 tackles, 67 quarterback sacks, and 17 forced fumbles.